Comparative Evaluation of Metformin and Metronidazole Release from Oral Lyophilisates with Different Methods

The aim of this study is to compare three different dissolution methods assess the drug release from oral lyophilisates, based on interpolyelectrolyte complexes (IPECs). IPECs were prepared by mixing solutions a linear polymer, Eudragit® EPO, with polymer cross-linked structure, Noveon® AA-1 or Carbopol® 10 Ultrez (in ratios 1:2 and 1:1, respectively). Metformin metronidazole used as model drugs achieve systemic local effect. A comparative assessment kinetics was carried out using artificial saliva set-ups: paddle stirrer (USP apparatus 2), flow cell 4) Franz diffusion cell. results demonstrated that lyophilisates disintegrated within 1 min. In case metformin, completed in about 90 min independently set-up. static conditions USP 2 permitted aggregation IPEC; therefore, profiles show significant difference compared 4.